sensitivity and specificity of adenosine deaminase in diagnosis of juvenile idiopathic arthritis

نویسندگان

mina doudkani-fard growth and development research center, tehran university of medical sciences, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences)سازمان های دیگر: growth and development research center

vahid ziaee pediatric rheumatology research group, rheumatology research center, tehran university of medical sciences and department of pediatrics, tehran university of medical sciences, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences)سازمان های دیگر: pediatric rheumatology research group

rheumatology research center,

mohamad-hassan moradinejad department of pediatrics, children’s medical center, pediatrics center of excellence, tehran university of medical sciences, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences)سازمان های دیگر: children’s medical center

چکیده

background :juvenile idiopathic arthritis (jia) is one of the most common chronic rheumatic diseases in children with unknown etiology and pathogenesis. it also has no diagnostic test and its clinical diagnosis is made through ruling out other types of arthritis. the aim of this study was to evaluate the level of ada (adenosine deaminase) in the serum of jia patients and to compare it with that of patients with reactive arthritis (ra). evaluation of sensitivity and specificity of serum ada level in jia was another objective.   methods : the study included 120 children with jia (mean age= 7.6 ± 4.3 years) and 40 children with ra (mean age= 5.5 ± 3.1 years). the ada was measured in the active phase of both diseases.   results : the mean ada serum level was obtained as 15.8 ± 11.8 u/l in jia patients and 14.3 ± 7.5 u/l in ra patients. the difference was statistically insignificant (p=0.4). another finding of this study was the significant specificity (77.5%) of this laboratory parameter for jia in comparison with its low sensitivity (36.7%). positive predictive value was 83% and negative predictive value 29%.   conclusion : determination of ada serum levels is a noninvasive reliable and easy biomarker for diagnosis of jia and it can be used as alternative parameters representing disease activity.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Sensitivity and specificity of adenosine deaminase in diagnosis of juvenile idiopathic arthritis

  Background :Juvenile Idiopathic Arthritis (JIA) is one of the most common chronic rheumatic diseases in children with unknown etiology and pathogenesis. It also has no diagnostic test and its clinical diagnosis is made through ruling out other types of arthritis. The aim of this study was to evaluate the level of ADA (Adenosine Deaminase) in the serum of JIA patients and to compare it with th...

متن کامل

Sensitivity and specificity of adenosine deaminase in diagnosis of juvenile idiopathic arthritis

BACKGROUND Juvenile Idiopathic Arthritis (JIA) is one of the most common chronic rheumatic diseases inchildren with unknown etiology and pathogenesis. It also has no diagnostic test and its clinical diagnosis ismade through ruling out other types of arthritis. The aim of this study was to evaluate the level of ADA (AdenosineDeaminase) in the serum of JIA patients and to compare it with that of ...

متن کامل

Sensitivity And Specificity Of Procalcitonin In Diagnosis Of Neonatal Sepsis

  Background and Objective: According to the fact that neonatal infection is a challenging diagnosis field, several studies have tried to test sensitivity and specificity of diagnostic tests. This study was conducted to evaluate the sensitivity and specificity of procalcitonin (PCT) as a single early marker of neonatal sepsis. Materials and Methods: In this study, 150 neonates admitted to NIC...

متن کامل

Juvenile idiopathic arthritis: Diagnosis and differential diagnosis

Juvenile idiopathic arthritis (JIA) is comprised of a heterogeneous group of several disease subtypes that are characterized by the onset of arthritis before the age of 16 years and has symptoms lasting at least 6 weeks. The previous classification of JIA included seven different categories, whereas its current classification was compiled by the International League of the Association for Rheum...

متن کامل

Diagnosis and management of juvenile idiopathic arthritis.

Juvenile idiopathic arthritis is the most common cause of chronic arthritis in childhood; a review of 34 epidemiological studies showed that 0.07-4.01 per 1000 children worldwide are affected. It is characterised by joint inflammation that often leads to joint destruction with physical disability and chronic pain that affects daily life. During the past decade, increased understanding of the di...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
medical journal of islamic republic of iran

جلد ۲۸، شماره ۱، صفحات ۷۴۷-۷۵۱

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023